![]() CPET can help noninvasively detect PH and identify patients at risk. This study provided initial data on CPET among patients having CPFE with and without PH. Combining peak AaDO2 >60 mm Hg with peak VO2/body weight/min <16.5 mL/kg/min provided a sensitivity and specificity of 100 and 95.5%, respectively. 8.1 ± 3.6 mm Hg) were observed between patients with and without PH (p 60 mm Hg had a specificity and sensitivity of 95.5 and 84.2%, respectively. Significant differences in peak VO2 (861 ± 190 vs. Right heart catheterization was performed in 15 of 41 patients without clinically relevant complications. CPET parameters, such as peak oxygen uptake (peak VO2), functional dead space ventilation (VDf/VT), alveolar-arterial oxygen difference (AaDO2), arterial-end-tidal CO2 difference at peak exercise, and the minute ventilation-carbon dioxide production relationship (VE/VCO2 slope), were compared between patients with and without PH.Ī total of 41 patients with CPET (22 with PH, 19 without PH) were analyzed. Patients diagnosed with CPFE in 2 German cities (Hemer and Greifswald) over a period of 10 years were included herein. The current study aimed to determine whether cardiopulmonary exercise testing (CPET) can be helpful in differentiating patients having CPFE with and without PH. Notably, concomitant PH was identified as a negative prognostic indicator that could help with early diagnosis to provide important information regarding prognosis. Combined pulmonary fibrosis and emphysema (CPFE) is a distinct entity among fibrosing lung diseases with a high risk for lung cancer and pulmonary hypertension (PH).
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